Identification of 24 Unknown Substances (NIAS/IAS) from Food Contact Polycarbonate by LC-Orbitrap Tribrid HRMS-DDMS3: Safety Assessment

Twenty-four substances, mainly NIAS, have been tentatively identified in food contact polycarbonate through the application a new, fast, and automated analytical strategy for investigation of unknowns materials. Most compounds were plasticizers, slip agents, antioxidants, ultraviolet stabilizers fragrances, majority them not previously PC The workflow setup includes an intelligent data acquisition applied using LC-Orbitrap Tribrid-HRMS (MS3), with processing Compound DiscovererTM. To obtain high confidence identification unknown very strict criterion has established, which comprises exact mass, isotopic profile, MS2 match, retention time, MS3 match. check safety migration from polycarbonate, risk assessment was achieved threshold toxicological concern (TTC) approach. Except agent hexadecanamide, do represent risk.